Regulation of Global and Specific mRNA Translation by Amino Acids
نویسندگان
چکیده
منابع مشابه
Amino Acids: Regulation of Global and Specific mRNA Translation
Maintenance of optimal rates of protein synthesis in both liver and skeletal muscle requires a continuous supply of essential amino acids is a prerequisite for. Deprivation of even a single essential amino acid causes a decrease in the synthesis of essentially all cellular proteins through an inhibition of the initiation phase of mRNA translation. However, the synthesis of all proteins is not r...
متن کاملmRNA-specific regulation of translation by poly(A)-binding proteins.
The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of disease. Numerous studies have highlighted the diverse, and sometimes related, mechanisms which underlie the regulation of global translation rates and the translational control of specific mRNAs. In the present paper, we discuss the emergi...
متن کاملRegulation of mRNA translation by signaling pathways.
mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of compo...
متن کاملRegulation of mRNA translation.
The control of mRNA translation plays an important role in regulating gene expression in diverse situations. Nutrients, especially amino acids, regulate translation to control the expression of specific proteins including transcriptional activators and ribosomal proteins. Sequence elements in the 5'- or 3'-untranslated regions of mRNAs can control their translation. Hormones such as insulin act...
متن کاملRegulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs.
Previous studies have shown that intravenous infusion of insulin and/or amino acids reproduces the feeding-induced stimulation of muscle protein synthesis in neonates and that insulin and amino acids act independently to produce this effect. The goal of the present study was to delineate the regulatory roles of insulin and amino acids on muscle protein synthesis in neonates by examining transla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2002
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/132.5.883